Professor Wei Chen, PhD

Education

1983 - 1988 Ph.D. in biophysics and physiology
     School of Medicine, Temple University, Philadelphia, Pennsylvania
1977 - 1982 B.S. Major in electronic physics and minor in optic physics,
     Department of Physics, Nankai University, Tianjing, China

Experience

2002 - PRESENT Professor, Department of Physics, University of South Florida
1997 - 2001 Assistant Professor and Associate Professor
     Departments of Dermatology; Physiology and Biophysics, and Bioengineering
     School of Medicine, University of Illinois, Chicago
1993 - 1996 Research Assistant Professor
     Department of Surgery, Section of Plastic and Reconstructive Surgery
     University of Chicago, School of Medicine
1989 - 1992 Postdoctoral Research Associate
     Department of Physiology and Biophysics
     School of Medicine, Indiana University

Honors

2012 - present Editorial Board Member, Bioenergetics
2008 - present Editorial Board Member, Journal of Bioelectromagnetics
2005 - HaiTian Professor, Darlian University of Science and Technology, Darlian, China
2005 - Council Member, American Society of Physical Regulation in Biology and Medicine
1999 ACDR Award, American Dermatology Society
1999 Extra Mile Award, The University of Illinois, Chicago
1995 - Honorary Professor, Tsinghua University, Beijing, China
1984 - 1987 University Fellowship, Temple University
1986 International Biostructure Conference Fellowship, (NATO) Rome, Italy
1985 International Biostructure Conference Fellowship, (NATO) Rome, Italy

Funding Agencies

NIH
NSF
American Heart Association
American Dermatology Association
The University of Chicago
The University of Illinois

Professional Societies

Biophysical Society
Bioelectromagnetics
Society of Physical Regulation in Biology and Medicine
Bioelectrochemistry Society

Selected Publications

  • Vu Tran, Xiaodong Zhang, Lin Cao, Hanqing Li, Benjamin Lee, Michelle So, Yaohui Sun, Wei Chen, Min Zhao, Synchronization Modulation Increases Transepithelial Potentials through Na/K Pumps, 2012.
  • Mast, J., Bovin, M., Lanes, O., Chen, W., Effects of the synchronization modulation electric field on muscle fatigue, Bioenergetics. 2012
  • Huang, F., Fang, Z.H., Mast, J., and Chen, W., Comparison of Membrane Electroporation and Protein Denature in Responding to Pulsed Electric Field with Different Durations, Bioelectromagnetics, 2012
  • Dando, R., Fang, Z.H., and Chen, W., Hyperpolarization of the Membrane Potential in Cardiomyocyte Tissue Slices by the Synchronization Modulation Electric Field. J Membrane Biol., 245:97105, 2012.
  • Zhang, L.P., Fang, Z.H., and Chen, W., Quick and effective hyperpolarization of the membrane potential in intact smooth muscle cells of blood vessels by synchronization modulation electric field. Journal of Biomembrane and Bioenergetics, Jun;44(3):385-95. Epub 2012 Mar 28, 2012.
  • Huang, R., Rabson, D., Chen, W., Distribution of the Na/K Pumps Turnover Rates As a Function of Membrane Potential, Temperature, and Ion Concentration Gradients and Effect of Fluctuations, Journal of Physical Chemistry B, 2009, 113 (23), pp 8096-8102
  • Chen, W. and Huang, F., Computer simulation of Synchronization of Na/K pump molecules, Journal of Bioenergetics and Biomembrane, Aug 5. [Epub ahead of print], 2008
  • Chen, W., Zhang, Z.S., and Huang, F., Synchronization of the Na/K pumps by an oscillating electric field, Journal of Bioenergetics and Biomembrane, Aug 2. [Epub ahead of print], 2008
  • Chen, W., Synchronization of carrier-mediated pump molecules by an oscillating electric field: Theory, Journal of Physical Chemistry B, 112(32), 10064-70, 2008
  • Chen, W., and Dando, R., Cellular recovery from electrooration using synchronization modulation as rescue model for electrically injured cells, Burns, May 26. [Epub ahead of print], 2008
  • Chen, W., and Dando, R., Membrane potential hyperpolarization in mammalian cardiac cells by synchronization Modulation of Na/K Pumps, Journal of Membrane Biology, Feb;221(3):165-73. 2008
  • Chen, W., Zhang, Z. S. and Huang, F., Entrainment of Na/K pumps by synchronization modulation electric field, Journal of Bioenergetics and Biomembrane 39:331-339, 2007
  • Chen, W., Dando, R., Synchronization modulation of Na/K pump molecules can hyperpolarize the membrane resting potential in intact fibers, Journal of Bioenergetic and Biomembrane 39:117-26. 2007
  • Chen, W., and Wang, L., Synchronization modulation of the Na/K pump molecules can hyperpolarize the membrane potential of PC 12 cells, Molecular and Cellular Biomechanics, V3(4): 203-204, 2006
  • Chen, W., and Dando, R., Electrical activation of Na/K pumps can increase ionic concentration gradient and membrane resting potential. J. Membrane Biology, 214:147-155, 2006
  • Chen, W., Dando, R., Synchronization Modulation of Na/K Pump Molecules Can Hyperpolarize the Membrane Resting Potential in Intact Fibers, Journal of Bioenergetics and Biomembranes, 10.1007/s10863-006-9068-4 (online), 2006
  • Chen W, Zhang ZS, Synchronization of Na/K pump molecules by a train of squared pulses. Journal of bioenergetics and biomembranes Dec;38(5-6):319-25, 2006
  • Chen, W., Zhang, Z.S., and Lee, R., Supramembrane potential-induced electroconformational changes in sodium channel proteins: A potential mechanism involved in electric injury. Burns, (32)52-59, 2006
  • Chen, W., Ter-Antonyan, V., Kay, H., and Salewski, M. Trans-dermal drug delivery through the sweat glands, Drug delivery (6)7:42-47, 2006
  • Chen, W., and Wu, Wenhui., Electric field-induced changes in membrane proteins charge movement currents, Burns, (32)833-841, 2006.
  • Chen W, Voltage dependence of the carrier-mediated ion transport. Physical review. E, Statistical, nonlinear, and soft matter physics Feb;73(2 Pt 1):021902-1-7. 2006
  • Chen, W, Zhang, Z.S., and Lee, R.C., Supramembrane potential-induced electroconformational change in sodium channel proteins: A potential mechanism involved in electric injury, Burns, 32:52-59, 2006.
  • Chen, W. Electroconformational Denature of Membrane Proteins. Annul N.Y. Acad. Sci, (1066):92-105, 2005.
  • Bier, M., Chen. W., Bodnar, E., and Lee, R., Biophysical injury mechanisms associated with lightning injury, NeuroRehabilitation, 20(53-62), 2005.
  • Bier, M., Gowrishanker, T. R., Chen, W. and Lee, R., Electroporation on a lipid bilayer as a chemical reaction, Bioelectromagnetism, 25:634-637, 2004.
  • Bier, M., W. Chen, T.R. Gowrishankar, R. D. Astumian, and R.C. Lee, The electroporation dynamics of cell membrane. Physical Review E (in press).
  • Chen, W. Evidence of electrocomformational changes in membrane proteins: field-induced reductions in intra membrane nonlinear charge movement currents, Bioelectrochemistry, 63:333-335, 2004.
  • Chen, W., Supra-physiological membrane potential induced conformational changes in K+ channel conducting system of frog skeletal muscles. Bioelectrochemistry, 62:47-56, 2004.
  • Bier, M., Chen, W., Gowrishankar, T.R., Austumian, R.D., and Lee, R.C., Resealing dynamics of a cell membrane after electroporation, Physics Rev. E. 66: 062905-1:4, 2002.
  • Gowrishankar, T.R., Chen, W., and Lee, R.C., Skeletal muscle membrane transport property responses to large induced transmembrane potentials: Relevance to electrical injury, Bioelectrochemistry and Bioenergetics (in press),
  • Chen, W., and Wu. W. H., The rectifier-like characteristics of the Na/K ATPase transient currents, Bioelectrochemistry 56:199-203, 2002.
  • Chen, W., Electroconformational changes in cell membrane proteins, pp. 147-207, in Advances in Electromagnetic Field in Living Systems, Ed. By Jams Linn,, Plenum Publishing Co. New York, 2001.
  • Chen W., Y. Han, Y. Chen. And R. C. Lee Supramembrane potential-induced electroconformational changes of the voltage-gated Na channels is a possible mechanism in electrical injury. Pp.837-840, Electricity and magnetism in Biology and Medicine, Ed. F. Bersani, Kuwer/Plenum, 1999.
  • Xie, J. T., Chen, W. And January, C. T., Effect of acetylstrophanthidin on action duration and relation with extracellular potassium in sheep isolated Purkinje fibers, Acta Pharmacologica Sinca, 19(4):309-312, 1999.
  • Chen, W., Y. Han and Y. Chen Activating the electrogenic molecular pumps, Na/K ATPases, by weak oscillating electrical fields, pp.568-569, Electricity and magnetism in Biology and Medicine, Ed. F. Bersani, Kuwer/Plenum, 1999.
  • Chen, W., Y. Han, Y. Chen and J. T. Xie, Field-Induced Electroconformational Damages in Cell membrane Proteins: A New Mechanism Involved in Electrical Injury, Bioelectrochemistry and Bioenergetics, 47:237-245, 1998.
  • Gowrishankar, T.R., Chen, W., and Lee, R.L., Non-linear microscale alterations in membrane transport by electropermeabilization, New York Annuals of Academy of Science, 1998.
  • Chen, W., Y. Han, Y. Chen and J. T. Xie, Field-Induced Electroconformational Damages in Cell membrane Proteins: A New Mechanism Involved in Electrical Injury, Bioelectrochemistry and Bioenergetics, 47:237-245, 1998.
  • Chen, W., Y. Han and D. Astumian, Electric field-induced functional reductions in the K channels mainly resulted from supramembrane potential-mediated electroconformational changes, Biophysical Journal, 75:196-206, 1998.
  • Hui, C.S. and Chen, W. Charge movement in cut twitch fibers of Rana temporaria containing 0.1 mM EGTA, Journal of Physiology, 503(3):563-570, 1997.
  • Lee, R.C., J. Arsvold, W. Chen, D. Astumian, M. Schellpfeffer, K. Kelley and N.H. Plishin, Biophysical mechanisms of cell membrane damage in electrical shock. Seminars in Neurology, V15(3):315-322, 1995.
  • Chen, W., and C.S. Hui, Differential suppression of charge movement component by gluconate in cut twich fiber of Rana Temporaria frog. Journal of Physiology, 489.2:511- 517,1995.
  • Chen, W. and Lee, R. C., Altered channel conductance and selectivity induced by imposed membrane potential pulses. Biophysics Journal. 67: 603-612, 1994.
  • Chen, W. and Lee, R. C., Electromediated permeabilization of frog skeletal muscle cell membrane: effect of voltage-gated ion channels, Bioelectrochemistry and Bioenergetics. 34(2):157-168, 1994.
  • Hui, C. S. and Chen, W, Origin of delayed outward ionic current in charge movement traces from frog skeletal muscle, Journal of Physiology. 479.1:109-125, 1994.
  • Xie, J.T., Chen, W. and January, C.T. Resibufogenin obtained from toad venom and its pharmacological and toxicological effects. Meth. Find Exp. Clin. Pharmacol., 15(10):689-697, 1994.
  • Chen, W. and Lee, R. C., An improved double vaseline gap voltage clamp to study electroporated skeletal muscle fibers. Biophysical Journal. 66:700-709, 1994.
  • Chen, W. Electroconformational damage of ionic channels under exposure to a high intensity electrical field, Annals of the New York Academy of Science. 1994,
  • Lee, R.C. and Chen, W., Kinetics of membrane sealing in electropermeabilized membrane, Annals of the New York Academy of Science. V720: 124-135, 1994,
  • Hui, C.S. and Chen. W. Evidence for the non-exitence of a negative phase in the hump charge movement component (I?) in Rana temporaia, Journal of Physiology. 474(2):275-282, 1994.
  • Hui, C.S. and Chen, W., The blockage of different Ca-dependent Cl channel blockers on the slow tail of the off charge movements in frog cut twitch fiber. Journal of Physiology. 479(1):109-126, 1994,
  • Chen, W. and Lee, R. C., Electro-permeabliztion of skeletal muscle cell membrane: effect of voltage-gated protein channels, 10th International Biophysics Congress, PP.114, 1993.
  • Hui, C.S. and Chen, W. Effects of conditioning depolarization and repetitive stimulation on Q beta and Q gamma charge components in frog cut twitch fibers. Journal of General Physiology. 99:1017-1043, 1992.
  • Hui, C.S. and Chen, W. Separation of Q beta, and Qgamma, charge components in frog cut twitch fibers with tetracaine: critical comparison with other methods. Journal of General Physiology. 99: 985-1016. 1992.
  • Chen, W. and Hui, C. S., Differential blockage of charge movement components in frog cut twitch fibers by nifedipine. Journal of Physiology. 444:579-603, 1991.
  • Chen, W. and Hui, C. S., Existence of Q gamma, in frog cut twitch fibers with little Q beta. Biophysical Journal. V59:503-507, 1991.